Amphiphilic DTPA Multimer Assembled on Icosahedral Closo-Borane Motif as High-Performance MRI Blood Pool Contrast Agent.
ACS Appl Bio Mater
; 4(9): 6658-6663, 2021 09 20.
Article
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| MEDLINE
| ID: mdl-35006969
ABSTRACT
A multimeric MRI blood pool contrast agent based on the closo-borane motif is reported. Twelve copies of an amphiphilic DTPA chelate with amine end groups are appended on carbonate-functionalized closo-borane motif using carbamate linkages. The presence of peripheral phenyl groups on the modified DTPA chelates results in high human serum albumin binding, high relaxivity, and excellent contrast enhancement in vitro and in vivo.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Boranos
/
Medios de Contraste
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article