Photoredox-Catalyzed Cascade of <i>o-</i>Hydroxyarylenaminones to Access 3-Aminated Chromones.

Wang, Zhi-Wei; Zheng, Yu; Qian, Yu-En; Guan, Jian-Ping; Lu, Wei-Dong; Yuan, Chu-Ping; Xiao, Jun-An; Chen, Kai; Xiang, Hao-Yue; Yang, Hua

Photoredox-Catalyzed Cascade of o-Hydroxyarylenaminones to Access 3-Aminated Chromones.

Wang, Zhi-Wei; Zheng, Yu; Qian, Yu-En; Guan, Jian-Ping; Lu, Wei-Dong; Yuan, Chu-Ping; Xiao, Jun-An; Chen, Kai; Xiang, Hao-Yue; Yang, Hua.

Wang ZW; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China.
Zheng Y; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China.
Qian YE; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China.
Guan JP; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China.
Lu WD; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China.
Yuan CP; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China.
Xiao JA; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning 530001, P.R. China.
Chen K; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China.
Xiang HY; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China.
Yang H; School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, Henan, P.R. China.

J Org Chem ; 87(2): 1477-1484, 2022 01 21.

Article en En | MEDLINE | ID: mdl-35014269

ABSTRACT

ABSTRACT

Reported herein is a photoredox-catalyzed amination of o-hydroxyarylenaminones with tert-butyl ((perfluoropyridin-4-yl)oxy)carbamate, a versatile amidyl-radical precursor developed in our laboratory. This work establishes a new cascade pathway for the assembly of a range of 3-aminochromones under mild conditions. Downstream transformations of the obtained 3-aminochromones to construct diverse amino pyrimidines greatly broaden the applications of this photocatalyzed protocol.

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Cromonas; Aminación; Catálisis

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