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Apigenin regulates the migration, invasion, and autophagy of hepatocellular carcinoma cells by downregulating YAP.
Zeng, Jing; Xie, Hua; Zhang, Zhi-Lin; Li, Zi-Xian; Shi, Lin; Wu, Ke-Yan; Zhou, Yang; Tian, Zhen; Zhang, Yu; Zhou, Wei; Shen, Wei-Gan.
  • Zeng J; Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu, China.
  • Xie H; Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu, China.
  • Zhang ZL; Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu, China.
  • Li ZX; Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu, China.
  • Shi L; Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu, China.
  • Wu KY; Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu, China.
  • Zhou Y; Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
  • Tian Z; Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu, China.
  • Zhang Y; Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu, China.
  • Zhou W; Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu, China.
  • Shen WG; Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu, China.
Neoplasma ; 69(2): 292-302, 2022 Mar.
Article en En | MEDLINE | ID: mdl-35014535
ABSTRACT
Apigenin is an edible flavonoid with anticancer properties; however, the underlying mechanisms in hepatocellular carcinoma (HCC) remain to be clarified. In the present study, we demonstrated that apigenin decreased the viability of both SMMC-7721 and SK-Hep1 cells in a dose-dependent manner, and inhibited the migration and invasion of HCC cells with different metastatic potential by regulating actin cytoskeletal rearrangements. Moreover, we showed that apigenin decreased the expression of YAP, and subsequently reduced migration and invasion by modulating the expression of the epithelial-mesenchymal transition (EMT) markers, and promoted the autophagy of HCC cells by regulating the expression of autophagy-related genes. Collectively, the present findings might provide a novel mechanism for the therapeutic application of apigenin in HCC.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article