Clinical and direct immunofluorescence characteristics of cutaneous toxicity associated with enfortumab vedotin.
Br J Dermatol
; 187(1): 126-127, 2022 07.
Article
en En
| MEDLINE
| ID: mdl-35048357
ABSTRACT
Enfortumab vedotin (EV), a novel antibody-drug conjugate approved for metastatic urothelial carcinoma, causes a variety of cutaneous adverse reactions. We present two cases of bullous eruptions following treatment with EV, both demonstrating IgG deposition on direct immunofluorescence (DIF) correlating to the location of nectin-4 in the epidermis. This suggests that the IgG component of EV binding to nectin-4 in keratinocytes is likely a primary contributor to the high rates of cutaneous toxicity.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
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Carcinoma de Células Transicionales
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Erupciones por Medicamentos
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Anticuerpos Monoclonales
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article