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Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.
Risom, Tyler; Glass, David R; Averbukh, Inna; Liu, Candace C; Baranski, Alex; Kagel, Adam; McCaffrey, Erin F; Greenwald, Noah F; Rivero-Gutiérrez, Belén; Strand, Siri H; Varma, Sushama; Kong, Alex; Keren, Leeat; Srivastava, Sucheta; Zhu, Chunfang; Khair, Zumana; Veis, Deborah J; Deschryver, Katherine; Vennam, Sujay; Maley, Carlo; Hwang, E Shelley; Marks, Jeffrey R; Bendall, Sean C; Colditz, Graham A; West, Robert B; Angelo, Michael.
  • Risom T; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Department of Research Pathology, Genentech, South San Francisco, CA, USA.
  • Glass DR; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Averbukh I; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Liu CC; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Baranski A; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Kagel A; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • McCaffrey EF; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Greenwald NF; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Rivero-Gutiérrez B; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Strand SH; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Varma S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Kong A; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Keren L; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Srivastava S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Zhu C; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Khair Z; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Veis DJ; Departments of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  • Deschryver K; Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
  • Vennam S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Maley C; Biodesign institute, Arizona State University, Tempe, AZ, USA.
  • Hwang ES; Department of Surgery, Duke University, Durham, NC, USA.
  • Marks JR; Department of Surgery, Duke University, Durham, NC, USA.
  • Bendall SC; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Colditz GA; Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
  • West RB; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: rbwest@stanford.edu.
  • Angelo M; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Departments of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: mangelo0@stanford.edu.
Cell ; 185(2): 299-310.e18, 2022 01 20.
Article en En | MEDLINE | ID: mdl-35063072
ABSTRACT
Ductal carcinoma in situ (DCIS) is a pre-invasive lesion that is thought to be a precursor to invasive breast cancer (IBC). To understand the changes in the tumor microenvironment (TME) accompanying transition to IBC, we used multiplexed ion beam imaging by time of flight (MIBI-TOF) and a 37-plex antibody staining panel to interrogate 79 clinically annotated surgical resections using machine learning tools for cell segmentation, pixel-based clustering, and object morphometrics. Comparison of normal breast with patient-matched DCIS and IBC revealed coordinated transitions between four TME states that were delineated based on the location and function of myoepithelium, fibroblasts, and immune cells. Surprisingly, myoepithelial disruption was more advanced in DCIS patients that did not develop IBC, suggesting this process could be protective against recurrence. Taken together, this HTAN Breast PreCancer Atlas study offers insight into drivers of IBC relapse and emphasizes the importance of the TME in regulating these processes.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Año: 2022 Tipo del documento: Article