A Tissue Engineered Construct for Laryngeal Regeneration: A Proof-of-Concept Device Design Study.
Laryngoscope
; 132 Suppl 9: S1-S11, 2022 06.
Article
en En
| MEDLINE
| ID: mdl-35084750
ABSTRACT
OBJECTIVES/HYPOTHESIS:
Develop a patient-specific tissue engineered construct for laryngeal reconstruction following a partial laryngectomy. STUDYDESIGN:
Bench and animal research.METHODS:
A construct made from a porous polyethylene scaffold shaped in a canine-specific configuration and seeded with autologous canine adipose-derived stem cells in fibrin glue was implanted in a canine following a partial laryngectomy. After 1 year, the construct was first evaluated in vivo with high-speed imaging and acoustic-aerodynamic measures. It was then explanted and evaluated histologically.RESULTS:
The canine study at 1 year revealed the construct provided voicing (barking) with acoustic and aerodynamic measures within normal ranges. The canine was able to eat and breathe normally without long-term support. The construct was integrated with epithelialization of all areas except the medial portion of the vocal fold structure. No anti-infective agents were needed after the standard perioperative medications were completed.CONCLUSION:
This study provided a successful first step toward developing a patient-specific composite construct for patients undergoing partial laryngectomies. LEVEL OF EVIDENCE NA Laryngoscope, 132S1-S11, 2022.Palabras clave
Texto completo:
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Banco de datos:
MEDLINE
Asunto principal:
Ingeniería de Tejidos
/
Laringe
Límite:
Animals
/
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article