Dienylation of N-benzoylhydrazones with CF3-substituted homoallenylboronates in water.
Org Biomol Chem
; 20(7): 1386-1390, 2022 02 16.
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| MEDLINE
| ID: mdl-35088801
ABSTRACT
A convenient method for the dienylation of N-benzoylhydrazones in water has been developed. This protocol expanded the synthetic application of functionalized homoallenylboronates to provide the useful 2-aminomethyl-1,3-diene derivatives with high efficiency (up to 99% yield) and stereoselectivity without using any catalyst, additive or inert atmosphere. Furthermore, the transformation of a 2-aminomethyl-1,3-diene derivative to synthesize a functionalized pyrrolidine derivative was also explored.
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