Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.

Tyagi, Anu; Ahmed, Tofayel; Jian, Shi; Bajaj, Saumya; Ong, Seow Theng; Goay, Stephanie Shee Min; Zhao, Yue; Vorobyov, Igor; Tian, Changlin; Chandy, K George; Bhushan, Shashi

Tyagi, Anu; Ahmed, Tofayel; Jian, Shi; Bajaj, Saumya; Ong, Seow Theng; Goay, Stephanie Shee Min; Zhao, Yue; Vorobyov, Igor; Tian, Changlin; Chandy, K George; Bhushan, Shashi.

Tyagi A; School of Biological Sciences, Nanyang Technological University, Singapore 637551.
Ahmed T; Department of Structural Biology, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Jian S; Department of Biological Sciences, National University of Singapore, Singapore 117557.
Bajaj S; School of Biological Sciences, Nanyang Technological University, Singapore 637551.
Ong ST; LKCMedicine-ICESing Ion Channel Platform, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore 636921.
Goay SSM; LKCMedicine-ICESing Ion Channel Platform, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore 636921.
Zhao Y; LKCMedicine-ICESing Ion Channel Platform, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore 636921.
Vorobyov I; Hefei National Laboratory of Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China.
Tian C; Department of Physiology and Membrane Biology, University of California, Davis, CA 95616.
Chandy KG; Department of Pharmacology, University of California, Davis, CA 95616.
Bhushan S; Hefei National Laboratory of Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China.

Proc Natl Acad Sci U S A ; 119(5)2022 02 01.

Article en En | MEDLINE | ID: mdl-35091471

Asunto(s)

Canal de Potasio Kv1.3/metabolismo; Canal de Potasio Kv1.3/ultraestructura; Secuencia de Aminoácidos/genética; Sitios de Unión/fisiología; Humanos; Activación del Canal Iónico/fisiología; Canal de Potasio Kv1.3/efectos de los fármacos; Potenciales de la Membrana; Microscopía Electrónica/métodos; Modelos Moleculares; Conformación Molecular; Potasio/metabolismo; Canales de Potasio/metabolismo; Canales de Potasio/ultraestructura; Canales de Potasio con Entrada de Voltaje/metabolismo; Canales de Potasio con Entrada de Voltaje/ultraestructura; Alineación de Secuencia/métodos

Palabras clave

ShK; dalazatide; ion channels; potassium channels; selectivity filter

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Canal de Potasio Kv1.3 Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Canal de Potasio Kv1.3 Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article