In vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-Î³1 in T cells.

Wada, Junya; Rathnayake, Udumbara; Jenkins, Lisa M; Singh, Avinash; Mohammadi, Moosa; Appella, Ettore; Randazzo, Paul A; Samelson, Lawrence E

In vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-Î³1 in T cells.

Wada, Junya; Rathnayake, Udumbara; Jenkins, Lisa M; Singh, Avinash; Mohammadi, Moosa; Appella, Ettore; Randazzo, Paul A; Samelson, Lawrence E.

Wada J; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Rathnayake U; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Jenkins LM; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Singh A; Department of Biochemistry and Molecular Pharmacology, School of Medicine, Langone Medical Center, New York University, New York, New York, USA.
Mohammadi M; Department of Biochemistry and Molecular Pharmacology, School of Medicine, Langone Medical Center, New York University, New York, New York, USA.
Appella E; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Randazzo PA; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Samelson LE; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Electronic address: samelsonl@helix.nih.gov.

J Biol Chem ; 298(3): 101680, 2022 03.

Article en En | MEDLINE | ID: mdl-35124007

Asunto(s)

Fosfolipasa C gamma; Transducción de Señal; Linfocitos T; Activación Enzimática; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Fosfolipasa C gamma/genética; Fosfolipasa C gamma/metabolismo; Fosforilación; Receptores de Antígenos de Linfocitos T/metabolismo; Linfocitos T/enzimología; Linfocitos T/metabolismo

Palabras clave

T cell activation; in vitro reconstitution; phospholipase C; tyrosine phosphorylation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linfocitos T / Transducción de Señal / Fosfolipasa C gamma Idioma: En Año: 2022 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linfocitos T / Transducción de Señal / Fosfolipasa C gamma Idioma: En Año: 2022 Tipo del documento: Article