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Limonoids from the fruits of Chisocheton lasiocarpus (Meliaceae).
Katja, Dewa Gede; Hilmayanti, Erina; Mayanti, Tri; Harneti, Desi; Maharani, Rani; Farabi, Kindi; Lesmana, Ronny; Fajriah, Sofa; Supratman, Unang; Azmi, Mohamad Nurul; Shiono, Yoshihito.
  • Katja DG; Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado 95115, Indonesia.
  • Hilmayanti E; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, West Java, Indonesia.
  • Nurlelasari; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, West Java, Indonesia.
  • Mayanti T; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, West Java, Indonesia.
  • Harneti D; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, West Java, Indonesia.
  • Maharani R; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, West Java, Indonesia.
  • Farabi K; Central Laboratory of Universitas Padjadjaran, Jatinangor, Sumedang 45363, Indonesia.
  • Darwati; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, West Java, Indonesia.
  • Lesmana R; Central Laboratory of Universitas Padjadjaran, Jatinangor, Sumedang 45363, Indonesia.
  • Fajriah S; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, West Java, Indonesia.
  • Supratman U; Central Laboratory of Universitas Padjadjaran, Jatinangor, Sumedang 45363, Indonesia.
  • Azmi MN; Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Shiono Y; Research Center for Chemistry, Indonesian Science Institute, Serpong 15311, South Tangerang, Indonesia.
J Asian Nat Prod Res ; 25(1): 36-43, 2023 Jan.
Article en En | MEDLINE | ID: mdl-35128999
ABSTRACT
Two new azadirone-type limonoids, namely lasiocarpine A (1) and lasiocarpine B (2) were isolated from the fruit of Chisocheton lasiocarpus along with three known limonoids (3-5). UV, IR, one- and two- dimensional NMR, and mass spectrometry were used to determine the chemical structure of the isolated compounds. Furthermore, their cytotoxic activity against breast cancer cell line MCF-7 was evaluated using PrestoBlue reagent. From these compounds, lasiocarpine A (1) showed the strongest activity with an IC50 value of 43.38 µM.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Meliaceae / Limoninas / Antineoplásicos Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Meliaceae / Limoninas / Antineoplásicos Idioma: En Año: 2023 Tipo del documento: Article