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Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.
Winter-Holt, Jon J; Bardelle, Catherine; Chiarparin, Elisabetta; Dale, Ian L; Davey, Paul R J; Davies, Nichola L; Denz, Christopher; Fillery, Shaun M; Guérot, Carine M; Han, Fujin; Hughes, Samantha J; Kulkarni, Meghana; Liu, Zhaoqun; Milbradt, Alexander; Moss, Thomas A; Niu, Huijun; Patel, Joe; Rabow, Alfred A; Schimpl, Marianne; Shi, Junjie; Sun, Dongqing; Yang, Dejian; Guichard, Sylvie.
  • Bardelle C; BioPharmaceuticals R&D, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.
  • Denz C; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Han F; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Kulkarni M; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Liu Z; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Niu H; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Shi J; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Sun D; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Yang D; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Guichard S; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
J Med Chem ; 65(4): 3306-3331, 2022 02 24.
Article en En | MEDLINE | ID: mdl-35133824
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas de Unión al ADN / ATPasas Asociadas con Actividades Celulares Diversas / Antineoplásicos Límite: Female / Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas de Unión al ADN / ATPasas Asociadas con Actividades Celulares Diversas / Antineoplásicos Límite: Female / Humans Idioma: En Año: 2022 Tipo del documento: Article