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EGFR Genotyping of Matched Urine, Plasma, and Tumor Tissue in Patients With Non-Small-Cell Lung Cancer Treated With Rociletinib, an EGFR Tyrosine Kinase Inhibitor.
Goldman, Jonathan W; Karlovich, Chris; Sequist, Lecia V; Melnikova, Vlada; Franovic, Aleksandra; Gadgeel, Shirish M; Reckamp, Karen L; Camidge, D Ross; Pérol, Maurice; Ou, Sai-Hong Ignatius; Liu, Stephen V; Yu, Helena A; Soria, Jean-Charles; Socinski, Mark A; Mekhail, Tarek M; Solomon, Benjamin J; Natale, Ronald B; Otterson, Gregory A; Papadimitrakopoulou, Vassiliki; Langer, Corey J; Neal, Joel W; Despain, Darrin; Yurasov, Sergey; Litten, Jason B; Erlander, Mark; Raponi, Mitch; Wakelee, Heather A.
  • Goldman JW; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Karlovich C; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Sequist LV; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Melnikova V; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Franovic A; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Gadgeel SM; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Reckamp KL; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Camidge DR; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Pérol M; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Ou SI; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Liu SV; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Yu HA; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Soria JC; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Socinski MA; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Mekhail TM; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Solomon BJ; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Natale RB; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Otterson GA; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Papadimitrakopoulou V; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Langer CJ; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Neal JW; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Despain D; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Yurasov S; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Litten JB; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Erlander M; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Raponi M; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
  • Wakelee HA; Jonathan W. Goldman, University of California Los Angeles; Ronald B. Natale, Cedars-Sinai Medical Center, Los Angeles; Vlada Melnikova, Aleksandra Franovic, and Mark Erlander, Trovagene, San Diego; Karen Reckamp, City of Hope Comprehensive Cancer Center, Duarte; Sai-Hong Ignatius Ou, University of C
JCO Precis Oncol ; 2: 1-13, 2018 Nov.
Article en En | MEDLINE | ID: mdl-35135111
ABSTRACT

PURPOSE:

Liquid biopsies represent an attractive alternative to tissue biopsies, particularly rebiopsies, in determining patient eligibility for targeted therapies. Clinical utility of urine genotyping, however, has not been explored extensively. We evaluated epidermal growth factor receptor (EGFR) T790M detection in matched urine, plasma, and tissue and the clinical outcomes of patients with advanced non-small-cell lung cancer treated with rociletinib.

METHODS:

Tissue (n = 540), plasma (n = 482), and urine (n = 213) were collected from evaluable patients enrolled in TIGER-X, a phase I/II study. Genotyping was performed by therascreen EGFR testing in tissue, BEAMing in plasma, and a quantitative short footprint assay (Trovera) in urine, which was used to further examine discordant samples.

RESULTS:

Positive percent agreement with tissue T790M results was similar for urine (82%; 142 of 173) and plasma (81%; 313 of 387) genotyping. Urine and plasma together identified more patients who were T790M positive (92%) than tissue alone (83%) among matched samples (n = 177). The ability to identify mutations in plasma was strongly associated with M stage (P < .001); rate of T790M detection for patients with M1a/M0 disease increased from 54% for plasma alone to 85% when urine and plasma were both examined. Objective response rates of patients who were T790M positive were comparable between tumor (34%), plasma (32%), and urine (37%).

CONCLUSION:

Clinical response to rociletinib was comparable irrespective of whether T790M status was identified by liquid or tissue biopsy. Combined, urine and plasma identified a higher percentage of patients who were T790M positive than tumor genotyping alone and improved detection of T790M, particularly in the absence of distant metastases. These findings support the noninvasive analysis of urine and plasma before tumor rebiopsy when assessing T790M status.
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Año: 2018 Tipo del documento: Article