Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection.
Annu Rev Immunol
; 40: 469-498, 2022 04 26.
Article
en En
| MEDLINE
| ID: mdl-35138947
ABSTRACT
Intracellular pathogens pose a significant threat to animals. In defense, innate immune sensors attempt to detect these pathogens using pattern recognition receptors that either directly detect microbial molecules or indirectly detect their pathogenic activity. These sensors trigger different forms of regulated cell death, including pyroptosis, apoptosis, and necroptosis, which eliminate the infected host cell niche while simultaneously promoting beneficial immune responses. These defenses force intracellular pathogens to evolve strategies to minimize or completely evade the sensors. In this review, we discuss recent advances in our understanding of the cytosolic pattern recognition receptors that drive cell death, including NLRP1, NLRP3, NLRP6, NLRP9, NLRC4, AIM2, IFI16, and ZBP1.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Inflamasomas
/
Piroptosis
Límite:
Animals
/
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article