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Cortical lesion hotspots and association of subpial lesions with disability in multiple sclerosis.
Beck, Erin S; Maranzano, Josefina; Luciano, Nicholas J; Parvathaneni, Prasanna; Filippini, Stefano; Morrison, Mark; Suto, Daniel J; Wu, Tianxia; van Gelderen, Peter; de Zwart, Jacco A; Antel, Samson; Fetco, Dumitru; Ohayon, Joan; Andrada, Frances; Mina, Yair; Thomas, Chevaz; Jacobson, Steve; Duyn, Jeff; Cortese, Irene; Narayanan, Sridar; Nair, Govind; Sati, Pascal; Reich, Daniel S.
  • Beck ES; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Maranzano J; McConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Department of Anatomy, University of Quebec in Trois-Rivières, Trois-Rivières, QC, Canada.
  • Luciano NJ; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Parvathaneni P; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Filippini S; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Morrison M; Department of Neurosciences, Drug and Child Health, University of Florence, Florence, Italy.
  • Suto DJ; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Wu T; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • van Gelderen P; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • de Zwart JA; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Antel S; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Fetco D; McConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Ohayon J; McConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Andrada F; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Mina Y; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Thomas C; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Jacobson S; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Duyn J; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Cortese I; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Narayanan S; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Nair G; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Sati P; McConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Reich DS; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Mult Scler ; 28(9): 1351-1363, 2022 08.
Article en En | MEDLINE | ID: mdl-35142571
BACKGROUND: Dramatic improvements in visualization of cortical (especially subpial) multiple sclerosis (MS) lesions allow assessment of impact on clinical course. OBJECTIVE: Characterize cortical lesions by 7 tesla (T) T2*-/T1-weighted magnetic resonance imaging (MRI); determine relationship with other MS pathology and contribution to disability. METHODS: Sixty-four adults with MS (45 relapsing-remitting/19 progressive) underwent 3 T brain/spine MRI, 7 T brain MRI, and clinical testing. RESULTS: Cortical lesions were found in 94% (progressive: median 56/range 2-203; relapsing-remitting: 15/0-168; p = 0.004). Lesion distribution across 50 cortical regions was nonuniform (p = 0.006), with highest lesion burden in supplementary motor cortex and highest prevalence in superior frontal gyrus. Leukocortical and white matter lesion volumes were strongly correlated (r = 0.58, p < 0.0001), while subpial and white matter lesion volumes were moderately correlated (r = 0.30, p = 0.002). Leukocortical (p = 0.02) but not subpial lesions (p = 0.40) were correlated with paramagnetic rim lesions; both were correlated with spinal cord lesions (p = 0.01). Cortical lesion volumes (total and subtypes) were correlated with expanded disability status scale, 25-foot timed walk, nine-hole peg test, and symbol digit modality test scores. CONCLUSION: Cortical lesions are highly prevalent and are associated with disability and progressive disease. Subpial lesion burden is not strongly correlated with white matter lesions, suggesting differences in inflammation and repair mechanisms.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Personas con Discapacidad / Sustancia Blanca / Esclerosis Múltiple Tipo de estudio: Risk_factors_studies Límite: Adult / Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Personas con Discapacidad / Sustancia Blanca / Esclerosis Múltiple Tipo de estudio: Risk_factors_studies Límite: Adult / Humans Idioma: En Año: 2022 Tipo del documento: Article