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Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.
Kajita, Yuichi; Ikeda, Shuhei; Yoshikawa, Masato; Fukuda, Hiromi; Watanabe, Etsurou; Yano, Jason; Lane, Weston; Miyamoto, Maki; Ishii, Tsuyoshi; Nishi, Toshiya; Koike, Tatsuki.
  • Kajita Y; Research, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Ikeda S; Research, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Yoshikawa M; Research, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Fukuda H; Research, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Watanabe E; Research, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Yano J; Takeda California Inc., 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Lane W; Takeda California Inc., 9625 Towne Centre Drive, San Diego, California 92121, United States.
  • Miyamoto M; Research, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Ishii T; Research, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Nishi T; Research, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Koike T; Research, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
J Med Chem ; 65(4): 3343-3358, 2022 02 24.
Article en En | MEDLINE | ID: mdl-35166541
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Inhibidores Enzimáticos / Colesterol 24-Hidroxilasa / Anticolesterolemiantes Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Inhibidores Enzimáticos / Colesterol 24-Hidroxilasa / Anticolesterolemiantes Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article