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Anhydrous calcium phosphate crystals stabilize DNA for dry storage.
Antkowiak, Philipp L; Koch, Julian; Rzepka, Przemyslaw; Nguyen, Bichlien H; Strauss, Karin; Stark, Wendelin J; Grass, Robert N.
  • Antkowiak PL; Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland. robert.grass@chem.ethz.ch.
  • Koch J; Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland. robert.grass@chem.ethz.ch.
  • Rzepka P; Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland. robert.grass@chem.ethz.ch.
  • Nguyen BH; Laboratory for Catalysis and Sustainable Chemistry, Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen, Switzerland.
  • Strauss K; Microsoft Research, 1 Microsoft Way, Redmond, WA 98052, USA.
  • Stark WJ; Microsoft Research, 1 Microsoft Way, Redmond, WA 98052, USA.
  • Grass RN; Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland. robert.grass@chem.ethz.ch.
Chem Commun (Camb) ; 58(19): 3174-3177, 2022 Mar 03.
Article en En | MEDLINE | ID: mdl-35171192
ABSTRACT
The resilience of ancient DNA (aDNA) in bone gives rise to the preservation of synthetic DNA with bioinorganic materials such as calcium phosphate (CaP). Accelerated aging experiments at elevated temperature and humidity displayed a positive effect of co-precipitated, crystalline dicalcium phosphate on the stability of synthetic DNA in contrast to amorphous CaP. Quantitative PXRD in combination with SEM and EDX measurements revealed distinct CaP phase transformations of calcium phosphate dihydrate (brushite) to anhydrous dicalcium phosphate (monetite) influencing DNA stability.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Fosfatos de Calcio / ADN Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Fosfatos de Calcio / ADN Idioma: En Año: 2022 Tipo del documento: Article