Age-Dependent Reduction in Asthmatic Pathology through Reprogramming of Postviral Inflammatory Responses.
J Immunol
; 208(6): 1467-1482, 2022 03 15.
Article
en En
| MEDLINE
| ID: mdl-35173037
ABSTRACT
Asthma is a chronic disease of childhood, but for unknown reasons, disease activity sometimes subsides as children mature. In this study, we present clinical and animal model evidence suggesting that the age dependency of childhood asthma stems from an evolving host response to respiratory viral infection. Using clinical data, we show that societal suppression of respiratory virus transmission during coronavirus disease 2019 lockdown disrupted the traditional age gradient in pediatric asthma exacerbations, connecting the phenomenon of asthma remission to virus exposure. In mice, we show that asthmatic lung pathology triggered by Sendai virus (SeV) or influenza A virus is highly age-sensitive robust in juvenile mice (4-6 wk old) but attenuated in mature mice (>3 mo old). Interestingly, allergen induction of the same asthmatic traits was less dependent on chronological age than viruses. Age-specific responses to SeV included a juvenile bias toward type 2 airway inflammation that emerged early in infection, whereas mature mice exhibited a more restricted bronchiolar distribution of infection that produced a distinct type 2 low inflammatory cytokine profile. In the basal state, aging produced changes to lung leukocyte burden, including the number and transcriptional landscape of alveolar macrophages (AMs). Importantly, depleting AMs in mature mice restored post-SeV pathology to juvenile levels. Thus, aging influences chronic outcomes of respiratory viral infection through regulation of the AM compartment and type 2 inflammatory responses to viruses. Our data provide insight into how asthma remission might develop in children.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
/
Infecciones por Respirovirus
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Asma
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Envejecimiento
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Factores de Edad
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Infecciones por Orthomyxoviridae
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Células Th2
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Virus Sendai
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Gripe Humana
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SARS-CoV-2
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
País como asunto:
America do norte
Idioma:
En
Año:
2022
Tipo del documento:
Article