Beyond protein modification: the rise of non-canonical ADP-ribosylation.
Biochem J
; 479(4): 463-477, 2022 02 17.
Article
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| MEDLINE
| ID: mdl-35175282
ABSTRACT
ADP-ribosylation has primarily been known as post-translational modification of proteins. As signalling strategy conserved in all domains of life, it modulates substrate activity, localisation, stability or interactions, thereby regulating a variety of cellular processes and microbial pathogenicity. Yet over the last years, there is increasing evidence of non-canonical forms of ADP-ribosylation that are catalysed by certain members of the ADP-ribosyltransferase family and go beyond traditional protein ADP-ribosylation signalling. New macromolecular targets such as nucleic acids and new ADP-ribose derivatives have been established, notably extending the repertoire of ADP-ribosylation signalling. Based on the physiological relevance known so far, non-canonical ADP-ribosylation deserves its recognition next to the traditional protein ADP-ribosylation modification and which we therefore review in the following.
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Banco de datos:
MEDLINE
Asunto principal:
ADP-Ribosilación
Idioma:
En
Año:
2022
Tipo del documento:
Article