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Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases.
Klejch, Tomás; Keough, Dianne T; King, Gordon; Dolezelová, Eva; Cesnek, Michal; Budesínský, Milos; Zíková, Alena; Janeba, Zlatko; Guddat, Luke W; Hocková, Dana.
  • Klejch T; The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague 6 CZ-16000, Czech Republic.
  • Keough DT; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia.
  • King G; The Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane 4072, Australia.
  • Dolezelová E; Institute of Parasitology, Biology Centre ASCR, Ceské Budejovice 37005, Czech Republic.
  • Cesnek M; The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague 6 CZ-16000, Czech Republic.
  • Budesínský M; The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague 6 CZ-16000, Czech Republic.
  • Zíková A; Institute of Parasitology, Biology Centre ASCR, Ceské Budejovice 37005, Czech Republic.
  • Janeba Z; Faculty of Science, University of South Bohemia, Ceské Budejovice 37005, Czech Republic.
  • Guddat LW; The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague 6 CZ-16000, Czech Republic.
  • Hocková D; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia.
J Med Chem ; 65(5): 4030-4057, 2022 03 10.
Article en En | MEDLINE | ID: mdl-35175749

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Parásitos / Pentosiltransferasa / Organofosfonatos / Antimaláricos Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Parásitos / Pentosiltransferasa / Organofosfonatos / Antimaláricos Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article