A novel carotenoid biosynthetic route via oxidosqualene.
Biochem Biophys Res Commun
; 599: 75-80, 2022 04 09.
Article
en En
| MEDLINE
| ID: mdl-35176628
ABSTRACT
Over 800 known carotenoids are synthesized from phytoene or 4,4'-diapophytoene (dehydrosqualene) characterized by three conjugated double bonds. In this paper, we report that carotenoid desaturase CrtN from Staphylococcus aureus and Methylomonas can accept oxidosqualene, which is the precursor for plant- or animal-type triterpenoids, yielding the yellow carotenoid pigments with 8, 9, or 10 conjugated double bonds. The resulting pathway is the second nonnatural route for carotenoid pigments and the first pathway for carotenoid pigments not biosynthesized via (diapo)phytoene.
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Banco de datos:
MEDLINE
Asunto principal:
Escualeno
/
Carotenoides
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Escherichia coli
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Vías Biosintéticas
Idioma:
En
Año:
2022
Tipo del documento:
Article