Medication-Related Osteonecrosis of the Jaw Associated in a Patient Treated With Etanercept.
J Craniofac Surg
; 33(7): e694-e696, 2022 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-35184115
ABSTRACT
ABSTRACT Medication-related osteonecrosis of the jaws (MRONJ) is defined as a pathologic condition affecting the maxillary and mandibular bones arising subsequently to pharmacological treatment with antiresorptive and antiangiogenic drugs.In this case report, the occurrence of MRONJ is described in a 66-year-old female patient affected by rheumatoid arthritis and treated with Etanercept, a Tumor Necrosis Factor (TNF)-a inhibitor. The patient developed a mandibular MRONJ following the extraction of teeth 3.4 and 3.5. The patient was then treated with conservative surgery of the necrotic bone. At 12-month follow-up complete resolution was observed. According to the data presented, the evaluation of the effects of new immunosuppressive biological therapies on the oral cavity appears of utmost importance in preventing the development of MRONJ. Although the risk related to TNF-a inhibitors has not been quantified yet, the clinician should be aware of the potential adverse effects on the oral cavity.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Osteonecrosis
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Conservadores de la Densidad Ósea
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Osteonecrosis de los Maxilares Asociada a Difosfonatos
Tipo de estudio:
Etiology_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article