Identification of novel susceptibility factors related to CP/CPPS-like symptoms: Evidence from a multicenter case-control study.
Prostate
; 82(7): 772-782, 2022 05.
Article
en En
| MEDLINE
| ID: mdl-35188987
ABSTRACT
BACKGROUND:
We aimed to systematically identify novel susceptible factors related to the occurrence and development of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)-like symptoms that were not limited to lifestyles or dietary habits in Chinese population.METHODS:
We recruited participants from three centers (Shanghai [northeast], Hefei [east], and Lanzhou [northwest]) from August 2020 to June 2021. Demographics, lifestyles, dietary habits, past medical history, and national institutes of health-chronic prostatitis symptom index (NIH-CPSI) were collected from the individuals via optimized questionnaires. Logistic regression analysis and multivariate adjustment models were used to calculate the odds ratio (OR) and 95% confidence interval (95% CI) to assess the association between these variables and CP/CPPS-like symptoms.RESULTS:
A total of 1851 participants were enrolled in this study (764 cases and 1087 controls). Age distributions differed between groups (median, range 32, 18-74 vs. 29, 18-70, p < 0.001). After adjustment, physicochemical occupational hazards were identified significantly related to CP/CPPS-like symptom occurrence and development (ORoccurrence 1.389, 95% CI 1.031-1.870, p < 0.001; ORdevelopment 2.222, 95% CI 1.464-3.372, p < 0.001); besides, greater than or equal to four ejaculations per week significantly increased the likelihood of CP/CPPS-like symptoms compared with one ejaculation per week (ORoccurrence 3.051, 95% CI 1.598-5.827, p = 0.001). For these patients, who were easily felt gastrointestinal discomfort caused by spicy food intake, they had a higher incidence to affect with CP/CPPS-like symptoms (ORoccurrence 2.258, 95% CI 1.858-2.745, p < 0.001). In addition, history of drug allergy and genitourinary infections were identified as independent susceptible factors for the occurrence of CP/CPPS-like symptoms (ORoccurrence 1.689, 95% CI 1.007-2.834, p = 0.047; ORoccurrence 3.442, 95% CI 2.202-5.382, p < 0.001, respectively), while the history of rheumatic immune diseases was found tightly associated with the development of CP/CPPS-like symptoms (ORdevelopment 2.002, 95% CI 1.008-4.058, p = 0.048).CONCLUSION:
Infection/inflammatory/immune-related disorders, novel dietary habits, and lifestyles associated with the susceptibility of CP/CPPS-like symptoms' occurrence and development are identified. Altering these irregular conditions serves as potential strategies for the treatment of patients with CP/CPPS-like symptoms.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Prostatitis
/
Dolor Crónico
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Humans
/
Male
País como asunto:
Asia
Idioma:
En
Año:
2022
Tipo del documento:
Article