Acremocholone, an Anti-Vibrio Steroid from the Marine Mesophotic Zone Ciocalypta Sponge-Associated Fungus Acremonium sp. NBUF150.
Chem Biodivers
; 19(4): e202200028, 2022 Apr.
Article
en En
| MEDLINE
| ID: mdl-35194947
ABSTRACT
Mesophotic coral ecosystems (MCEs) represent an underexplored source of intriguing natural products. Efforts to discover bioactive metabolites from sponge-associated fungi in MCEs identified a new steroid, acremocholone (1) and its three known analogs (2-4), from Acremonium sp. NBUF150. The Acremonium sp. NBUF150 was isolated from a Ciocalypta sponge located 70â
m deep within the South China Sea. The planar structures and absolute configuration of 1-4 were determined from NMR-derived spectroscopic data, HR-ESI-MS, and X-ray crystallography. Compound 1 exhibited antimicrobial inhibition against Vibrio scophthalmi, V.â
shilonii and V.â
brasiliensis at minimum inhibitory concentrations of 8 µg/mL; compound 2 inhibited V.â
shilonii and V.â
brasiliensis at 8 and 32â
µg/mL, respectively, and compound 4 inhibited growth of V.â
brasiliensis at 16â
µg/mL. Sponge associated fungi from MCEs represent a promising resource of anti-Vibrio drug leads for aquaculture use.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Poríferos
/
Acremonium
/
Antozoos
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Año:
2022
Tipo del documento:
Article