Effects of Vitamin E and Dietary Conditions on the Differentiation and Maturation of Osteoclast.
J Nutr Sci Vitaminol (Tokyo)
; 68(1): 73-77, 2022.
Article
en En
| MEDLINE
| ID: mdl-35228498
ABSTRACT
α-Tocopherol is reported to activate the differentiation and fusion of osteoclast, however, it is not clear whether the excessive intake of vitamin E is a risk for osteoporosis. To investigate the effects of vitamin E and the dietary conditions on the osteoclastogenesis, osteoclast differentiation was evaluated using the bone marrow cells collected from mice fed various dietary conditions. Not only α-tocopherol but also γ-tocotrienol activated osteoclast differentiation in mice fed normal diet. Formation of large multinucleated cells was significantly increased by stimulation of nuclear factor-kappa B ligand (RANKL) in mice fed vitamin E deficient diet and was suppressed by the addition of α-tocopherol. Furthermore, there was no effect on bone density and no difference in osteoclast differentiation from the bone marrow cells collected from mice fed a high-fat diet with 0 or 1,000 mg/kg diet of α-tocopherol and tocotrienol, respectively. These results suggest that different type of diet affect the activation of osteoclast by α-tocopherol.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Osteoclastos
/
Tocotrienoles
Límite:
Animals
Idioma:
En
Año:
2022
Tipo del documento:
Article