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Interaction of p10/p27 with macrophage migration inhibitory factor promotes avian leukosis virus subgroup J infection.
Yang, Kunmei; Yang, Jianhao; Zhou, Defang; Zhu, Mingjun; Du, Xusheng; Zhou, Jing; Liu, Shenglong; Cheng, Ziqiang.
  • Yang K; College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Taian 271018, China.
  • Yang J; College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Taian 271018, China.
  • Zhou D; College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Taian 271018, China.
  • Zhu M; College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Taian 271018, China.
  • Du X; College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Taian 271018, China.
  • Zhou J; College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Taian 271018, China.
  • Liu S; College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Taian 271018, China.
  • Cheng Z; College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Taian 271018, China. Electronic address: czqsd@126.com.
Vet Microbiol ; 267: 109389, 2022 Apr.
Article en En | MEDLINE | ID: mdl-35259599
Avian leukosis virus subgroup J (ALV-J), an oncogenic retrovirus, induces myelocytoma and various other tumors in broilers and layers. Many recent studies have shown that ALV-J can hijack host molecules to facilitate infection. However, the molecular mechanisms of this process are not clear. Here, we aimed to elucidate the molecular mechanisms contributing to ALV-J infection. ALV-J hijacked MIF via p10 and p27 to facilitate ALV-J infection. ALV-J persistently activated MIF expression in DF-1 cells, and MIF significantly facilitated ALV-J internalization and replication, which demonstrated by MIF overexpression and knockdown experiments and treatment with the MIF antagonist ISO-1. Furthermore, we found that the two subunit proteins of Gag, p10 and p27, interacted with MIF in the cytoplasm, respectively. These results suggested that the p10 and p27 subunit in Gag protein recruited MIF to promote ALV-J infection, providing insights into the roles of the p10/p27 and the host factor MIF in ALV-J infection. The finding may facilitate the development of new strategies for controlling ALV-J or retrovirus infections.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Leucosis Aviar / Factores Inhibidores de la Migración de Macrófagos / Virus de la Leucosis Aviar Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Leucosis Aviar / Factores Inhibidores de la Migración de Macrófagos / Virus de la Leucosis Aviar Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article