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Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering.
Heckel, Franziska; Turaj, Anna H; Fisher, Hayden; Chan, H T Claude; Marshall, Michael J E; Dadas, Osman; Penfold, Christine A; Inzhelevskaya, Tatyana; Mockridge, C Ian; Alvarado, Diego; Tews, Ivo; Keler, Tibor; Beers, Stephen A; Cragg, Mark S; Lim, Sean H.
  • Heckel F; Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Turaj AH; Cancer Research UK Research Centre, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Fisher H; Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Chan HTC; Cancer Research UK Research Centre, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Marshall MJE; Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Dadas O; Cancer Research UK Research Centre, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Penfold CA; Institute for Life Sciences, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, UK.
  • Inzhelevskaya T; Biological Sciences, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, UK.
  • Mockridge CI; Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Alvarado D; Cancer Research UK Research Centre, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Tews I; Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Keler T; Cancer Research UK Research Centre, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Beers SA; Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Cragg MS; Cancer Research UK Research Centre, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
  • Lim SH; Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
Commun Biol ; 5(1): 229, 2022 03 14.
Article en En | MEDLINE | ID: mdl-35288635
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antineoplásicos Inmunológicos / Neoplasias Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antineoplásicos Inmunológicos / Neoplasias Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article