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Targeting the E1 ubiquitin-activating enzyme (UBA1) improves elexacaftor/tezacaftor/ivacaftor efficacy towards F508del and rare misfolded CFTR mutants.
Borgo, Christian; D'Amore, Claudio; Capurro, Valeria; Tomati, Valeria; Sondo, Elvira; Cresta, Federico; Castellani, Carlo; Pedemonte, Nicoletta; Salvi, Mauro.
  • Borgo C; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131, Padova, Italy. christian.borgo@unipd.it.
  • D'Amore C; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131, Padova, Italy.
  • Capurro V; UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genova, Italy.
  • Tomati V; UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genova, Italy.
  • Sondo E; UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genova, Italy.
  • Cresta F; Centro Fibrosi Cistica, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Castellani C; Centro Fibrosi Cistica, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  • Pedemonte N; UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genova, Italy. nicolettapedemonte@gaslini.org.
  • Salvi M; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131, Padova, Italy. mauro.salvi@unipd.it.
Cell Mol Life Sci ; 79(4): 192, 2022 Mar 16.
Article en En | MEDLINE | ID: mdl-35292885
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazoles / Piridinas / Pirimidinas / Pirrolidinas / Sulfuros / Sulfonamidas / Quinolonas / Regulador de Conductancia de Transmembrana de Fibrosis Quística / Fibrosis Quística / Enzimas Activadoras de Ubiquitina Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazoles / Piridinas / Pirimidinas / Pirrolidinas / Sulfuros / Sulfonamidas / Quinolonas / Regulador de Conductancia de Transmembrana de Fibrosis Quística / Fibrosis Quística / Enzimas Activadoras de Ubiquitina Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article