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Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells.
Smalley, Joshua P; Baker, India M; Pytel, Wiktoria A; Lin, Li-Ying; Bowman, Karen J; Schwabe, John W R; Cowley, Shaun M; Hodgkinson, James T.
  • Smalley JP; Leicester Institute of Structural and Chemical Biology, School of Chemistry, University of Leicester, Leicester LE1 7RH, U.K.
  • Baker IM; Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K.
  • Pytel WA; Leicester Institute of Structural and Chemical Biology, School of Chemistry, University of Leicester, Leicester LE1 7RH, U.K.
  • Lin LY; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K.
  • Bowman KJ; Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K.
  • Schwabe JWR; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K.
  • Cowley SM; Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K.
  • Hodgkinson JT; Leicester Institute of Structural and Chemical Biology, School of Chemistry, University of Leicester, Leicester LE1 7RH, U.K.
J Med Chem ; 65(7): 5642-5659, 2022 04 14.
Article en En | MEDLINE | ID: mdl-35293758
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Histona Desacetilasas / Neoplasias Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Histona Desacetilasas / Neoplasias Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article