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Discovery of Reversible Covalent Bruton's Tyrosine Kinase Inhibitors PRN473 and PRN1008 (Rilzabrutinib).
Owens, Timothy D; Brameld, Ken A; Verner, Erik J; Ton, Tony; Li, Xiaoyan; Zhu, Jiang; Masjedizadeh, Mohammad R; Bradshaw, J Michael; Hill, Ronald J; Tam, Danny; Bisconte, Angelina; Kim, Eun Ok; Francesco, Michelle; Xing, Yan; Shu, Jin; Karr, Dane; LaStant, Jacob; Finkle, David; Loewenstein, Natalie; Haberstock-Debic, Helena; Taylor, Michael J; Nunn, Philip; Langrish, Claire L; Goldstein, David M.
  • Owens TD; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Brameld KA; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Verner EJ; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Ton T; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Li X; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Zhu J; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Masjedizadeh MR; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Bradshaw JM; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Hill RJ; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Tam D; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Bisconte A; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Kim EO; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Francesco M; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Xing Y; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Shu J; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Karr D; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • LaStant J; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Finkle D; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Loewenstein N; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Haberstock-Debic H; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Taylor MJ; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Nunn P; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Langrish CL; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
  • Goldstein DM; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.
J Med Chem ; 65(7): 5300-5316, 2022 04 14.
Article en En | MEDLINE | ID: mdl-35302767
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Inhibidores de Proteínas Quinasas Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Inhibidores de Proteínas Quinasas Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article