Thromboinflammation in Brain Ischemia: Recent Updates and Future Perspectives.
Stroke
; 53(5): 1487-1499, 2022 05.
Article
en En
| MEDLINE
| ID: mdl-35360931
ABSTRACT
Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal damage following the ischemic event. Hence, we here review the most recent updates on thromboinflammatory-dependent mediators relevant after stroke focusing on recent discoveries on platelet modulation, a potential regulation of the innate and adaptive immune system in thromboinflammation, utterly providing a thorough up-to-date overview of all therapeutic approaches currently undergoing clinical trial.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trombosis
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Isquemia Encefálica
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Accidente Cerebrovascular
Límite:
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article