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Genetic variants associated with longitudinal changes in brain structure across the lifespan.
Brouwer, Rachel M; Klein, Marieke; Grasby, Katrina L; Schnack, Hugo G; Jahanshad, Neda; Teeuw, Jalmar; Thomopoulos, Sophia I; Sprooten, Emma; Franz, Carol E; Gogtay, Nitin; Kremen, William S; Panizzon, Matthew S; Olde Loohuis, Loes M; Whelan, Christopher D; Aghajani, Moji; Alloza, Clara; Alnæs, Dag; Artiges, Eric; Ayesa-Arriola, Rosa; Barker, Gareth J; Bastin, Mark E; Blok, Elisabet; Bøen, Erlend; Breukelaar, Isabella A; Bright, Joanna K; Buimer, Elizabeth E L; Bülow, Robin; Cannon, Dara M; Ciufolini, Simone; Crossley, Nicolas A; Damatac, Christienne G; Dazzan, Paola; de Mol, Casper L; de Zwarte, Sonja M C; Desrivières, Sylvane; Díaz-Caneja, Covadonga M; Doan, Nhat Trung; Dohm, Katharina; Fröhner, Juliane H; Goltermann, Janik; Grigis, Antoine; Grotegerd, Dominik; Han, Laura K M; Harris, Mathew A; Hartman, Catharina A; Heany, Sarah J; Heindel, Walter; Heslenfeld, Dirk J; Hohmann, Sarah; Ittermann, Bernd.
  • Brouwer RM; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands. r.m2.brouwer@vu.nl.
  • Klein M; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands. r.m2.brouwer@vu.nl.
  • Grasby KL; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
  • Schnack HG; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Jahanshad N; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Teeuw J; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
  • Thomopoulos SI; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Sprooten E; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
  • Franz CE; Utrecht Institute of Linguistics OTS, Utrecht University, Utrecht, The Netherlands.
  • Gogtay N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
  • Kremen WS; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
  • Panizzon MS; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
  • Olde Loohuis LM; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Whelan CD; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
  • Aghajani M; American Psychiatric Association, Washington, DC, USA.
  • Alloza C; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
  • Alnæs D; VA San Diego Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
  • Artiges E; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
  • Ayesa-Arriola R; Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Barker GJ; Biogen Research and Development, Cambridge, MA, USA.
  • Bastin ME; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
  • Blok E; Institute of Education & Child Studies, Section Forensic Family & Youth Care, Leiden University, Leiden, The Netherlands.
  • Bøen E; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.
  • Breukelaar IA; NORMENT Centre, University of Oslo, Oslo, Norway.
  • Bright JK; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Buimer EEL; INSERM U1299 Trajectoires Développementales en Psychiatrie, Ecole Normale Supérieure Paris-Saclay, Université Paris Saclay, Université Paris Cité, CNRS UMR 9010; Centre Borelli, Gif-sur-Yvette, France.
  • Bülow R; Valdecilla Biomedical Research Institute (IDIVAL), Marqués de Valdecilla University Hospital (HUMV), School of Medicine, University of Cantabria, Santander, Spain.
  • Cannon DM; CIBERSAM, Biomedical Research Network on Mental Health Area, Santander, Spain.
  • Ciufolini S; Universidad de Cantabria, Santander, Spain.
  • Crossley NA; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Damatac CG; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.
  • Dazzan P; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • de Mol CL; Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.
  • de Zwarte SMC; Department of Child and Adolescent Psychiatry/Psychology, Sophia Children's Hospital, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Desrivières S; Psychosomatic and CL Psychiatry, Oslo University Hospital, Oslo, Norway.
  • Díaz-Caneja CM; Brain Dynamics Centre, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW, Australia.
  • Doan NT; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
  • Dohm K; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
  • Fröhner JH; Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
  • Goltermann J; Centre for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
  • Grigis A; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Grotegerd D; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Han LKM; Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Harris MA; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Hartman CA; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Heany SJ; Department of Neurology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Heindel W; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
  • Heslenfeld DJ; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Hohmann S; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.
  • Ittermann B; NORMENT Centre, University of Oslo, Oslo, Norway.
Nat Neurosci ; 25(4): 421-432, 2022 04.
Article en En | MEDLINE | ID: mdl-35383335
ABSTRACT
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Longevidad Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Longevidad Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article