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Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19.
Liu, Hengrui; Iketani, Sho; Zask, Arie; Khanizeman, Nisha; Bednarova, Eva; Forouhar, Farhad; Fowler, Brandon; Hong, Seo Jung; Mohri, Hiroshi; Nair, Manoj S; Huang, Yaoxing; Tay, Nicholas E S; Lee, Sumin; Karan, Charles; Resnick, Samuel J; Quinn, Colette; Li, Wenjing; Shion, Henry; Xia, Xin; Daniels, Jacob D; Bartolo-Cruz, Michelle; Farina, Marcelo; Rajbhandari, Presha; Jurtschenko, Christopher; Lauber, Matthew A; McDonald, Thomas; Stokes, Michael E; Hurst, Brett L; Rovis, Tomislav; Chavez, Alejandro; Ho, David D; Stockwell, Brent R.
  • Liu H; Department of Chemistry, Columbia University, New York, NY, 10027, USA.
  • Iketani S; Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Zask A; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Khanizeman N; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
  • Bednarova E; Department of Chemistry, Columbia University, New York, NY, 10027, USA.
  • Forouhar F; Department of Chemistry, Columbia University, New York, NY, 10027, USA.
  • Fowler B; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Hong SJ; Department of Chemistry, Columbia University, New York, NY, 10027, USA.
  • Mohri H; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Nair MS; Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Huang Y; Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Tay NES; Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Lee S; Department of Chemistry, Columbia University, New York, NY, 10027, USA.
  • Karan C; Department of Chemistry, Columbia University, New York, NY, 10027, USA.
  • Resnick SJ; Sulzberger Columbia Genome Center, Columbia University, New York, NY, 10032, USA.
  • Quinn C; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Li W; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Shion H; Waters Corporation, 34 Maple Street, Milford, MA, 01757, USA.
  • Xia X; Waters Corporation, 34 Maple Street, Milford, MA, 01757, USA.
  • Daniels JD; Waters Corporation, 34 Maple Street, Milford, MA, 01757, USA.
  • Bartolo-Cruz M; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
  • Farina M; Department of Pharmacology and Molecular Therapeutics, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Rajbhandari P; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
  • Jurtschenko C; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
  • Lauber MA; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
  • McDonald T; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
  • Stokes ME; Waters Corporation, 34 Maple Street, Milford, MA, 01757, USA.
  • Hurst BL; Waters Corporation, 34 Maple Street, Milford, MA, 01757, USA.
  • Rovis T; Waters Corporation, 34 Maple Street, Milford, MA, 01757, USA.
  • Chavez A; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
  • Ho DD; Institute for Antiviral Research, Utah State University, Logan, UT, 84322, USA.
  • Stockwell BR; Department of Chemistry, Columbia University, New York, NY, 10027, USA. tr2504@columbia.edu.
Nat Commun ; 13(1): 1891, 2022 04 07.
Article en En | MEDLINE | ID: mdl-35393402
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Inhibidores de Proteasas / Proteasas 3C de Coronavirus / Tratamiento Farmacológico de COVID-19 Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Inhibidores de Proteasas / Proteasas 3C de Coronavirus / Tratamiento Farmacológico de COVID-19 Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article