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Rediscovery of Methadone to Improve Outcomes in Pain Management.
Lai, Gloria; Aroke, Edwin N; Zhang, Sarah Jingying.
  • Lai G; Department of Anesthesiology, University of California San Francisco, San Francisco, CA.
  • Aroke EN; Nurse Anesthesia Program, School of Nursing, University of Alabama at Birmingham, Birmingham, AL.
  • Zhang SJ; Nurse Anesthesiology Program, School of Nursing, University of South Florida, Tampa, CA; Nurse Anesthesia Program, School of Nursing, Samuel Merritt University, Oakland, CA. Electronic address: sarahjingyingz@usf.edu.
J Perianesth Nurs ; 37(4): 425-434, 2022 08.
Article en En | MEDLINE | ID: mdl-35396188
ABSTRACT
Clinically, methadone is most known for its use in the treatment of opioid maintenance therapy. However, methadone's pharmacological profile makes it an excellent analgesic that can enhance acute and chronic pain management. It is a potent µ-receptor agonist with a longer elimination half-life than most clinically used opioids. In addition, methadone inhibits serotonin and norepinephrine uptake, and it is an N-methyl-D-aspartate antagonist. These distinct analgesic pathways mediate hyperalgesic, allodynic, and neuropathic pain. Its unique analgesic properties provide several essential benefits in perioperative use, neuropathic pain, cancer, and noncancer pain. Despite these proven clinical utilities, methadone has not been used widely to treat acute and chronic pain in opioid naïve patients. This article describes the unique pharmacology of methadone and provides emerging evidence to support its application in acute and chronic pain management. Pain management options and guidelines for surgical patients on methadone are discussed as well.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Metadona / Neuralgia Tipo de estudio: Guideline Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Metadona / Neuralgia Tipo de estudio: Guideline Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article