Construction of a two-dimensional artificial antioxidase for nanocatalytic rheumatoid arthritis treatment.
Nat Commun
; 13(1): 1988, 2022 04 13.
Article
en En
| MEDLINE
| ID: mdl-35418125
ABSTRACT
Constructing nanomaterials mimicking the coordination environments of natural enzymes may achieve biomimetic catalysis. Here we construct a two-dimensional (2D) metal-organic framework (MOF) nanosheet catalyst as an artificial antioxidase for nanocatalytic rheumatoid arthritis treatment. The 2D MOF periodically assembles numbers of manganese porphyrin molecules, which has a metal coordination geometry analogous to those of two typical antioxidases, human mitochondrial manganese superoxide dismutase (Mn-SOD) and human erythrocyte catalase. The zinc atoms of the 2D MOF regulate the metal-centered redox potential of coordinated manganese porphyrin ligand, endowing the nanosheet with both SOD- and catalase-like activities. Cellular experiments show unique anti-inflammatory and pro-biomineralization performances of the 2D MOF, while in vivo animal model further demonstrates its desirable antiarthritic efficacy. It is expected that such a nanocatalytic antioxidation concept may provide feasible approaches to future anti-inflammatory treatments.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Porfirinas
/
Artritis Reumatoide
/
Estructuras Metalorgánicas
Límite:
Animals
Idioma:
En
Año:
2022
Tipo del documento:
Article