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Piezoelectric ultrasound energy-harvesting device for deep brain stimulation and analgesia applications.
Zhang, Tao; Liang, Huageng; Wang, Zhen; Qiu, Chaorui; Peng, Yuan Bo; Zhu, Xinyu; Li, Jiapu; Ge, Xu; Xu, Jianbo; Huang, Xian; Tong, Junwei; Ou-Yang, Jun; Yang, Xiaofei; Li, Fei; Zhu, Benpeng.
  • Zhang T; School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China.
  • Liang H; Department of Urology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Wang Z; Department of Psychology, University of Texas at Arlington, Arlington, TX 76019, USA.
  • Qiu C; Electronic Materials Research Lab, Key Lab of Education Ministry/International Center for Dielectric Research, School of Electronic and Information Engineering, State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
  • Peng YB; Department of Psychology, University of Texas at Arlington, Arlington, TX 76019, USA.
  • Zhu X; School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China.
  • Li J; School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China.
  • Ge X; School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China.
  • Xu J; School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China.
  • Huang X; Department of Urology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Tong J; Department of Urology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Ou-Yang J; School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China.
  • Yang X; School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China.
  • Li F; Electronic Materials Research Lab, Key Lab of Education Ministry/International Center for Dielectric Research, School of Electronic and Information Engineering, State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
  • Zhu B; School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China.
Sci Adv ; 8(15): eabk0159, 2022 04 15.
Article en En | MEDLINE | ID: mdl-35427156
Supplying wireless power is a challenging technical problem of great importance for implantable biomedical devices. Here, we introduce a novel implantable piezoelectric ultrasound energy-harvesting device based on Sm-doped Pb(Mg1/3Nb2/3)O3-PbTiO3 (Sm-PMN-PT) single crystal. The output power density of this device can reach up to 1.1 W/cm2 in vitro, which is 18 times higher than the previous record (60 mW/cm2). After being implanted in the rat brain, under 1-MHz ultrasound with a safe intensity of 212 mW/cm2, the as-developed device can produce an instantaneous effective output power of 280 µW, which can immediately activate the periaqueductal gray brain area. The rat electrophysiological experiments under anesthesia and behavioral experiments demonstrate that our wireless-powered device is well qualified for deep brain stimulation and analgesia applications. These encouraging results provide new insights into the development of implantable devices in the future.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2022 Tipo del documento: Article