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The impact of age, sex, cardio-respiratory fitness, and cardiovascular disease risk on dynamic cerebral autoregulation and baroreflex sensitivity.
Maxwell, Joseph D; Bannell, Daniel J; Brislane, Aine; Carter, Sophie E; Miller, Gemma D; Roberts, Kirsty A; Hopkins, Nicola D; Low, David A; Carter, Howard H; Thompson, Andrew; Claassen, Jurgen A H R; Thijssen, Dick H J; Jones, Helen.
  • Maxwell JD; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Bannell DJ; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Brislane A; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Carter SE; School of Sport, York St. John University, York, UK.
  • Miller GD; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Roberts KA; School of Sport, York St. John University, York, UK.
  • Hopkins ND; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Low DA; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Carter HH; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Thompson A; Research Institute of Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Claassen JAHR; School of Sport Science, Exercise and Health, The University of Western Australia, Perth, Australia.
  • Thijssen DHJ; Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Jones H; Department of Geriatric Medicine and Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Eur J Appl Physiol ; 122(6): 1531-1541, 2022 Jun.
Article en En | MEDLINE | ID: mdl-35429292
ABSTRACT

BACKGROUND:

Humans display an age-related decline in cerebral blood flow and increase in blood pressure (BP), but changes in the underlying control mechanisms across the lifespan are less well understood. We aimed to; (1) examine the impact of age, sex, cardiovascular disease (CVD) risk, and cardio-respiratory fitness on dynamic cerebral autoregulation and cardiac baroreflex sensitivity, and (2) explore the relationships between dynamic cerebral autoregulation (dCA) and cardiac baroreflex sensitivity (cBRS).

METHODS:

206 participants aged 18-70 years were stratified into age categories. Cerebral blood flow velocity was measured using transcranial Doppler ultrasound. Repeated squat-stand manoeuvres were performed (0.10 Hz), and transfer function analysis was used to assess dCA and cBRS. Multivariable linear regression was used to examine the influence of age, sex, CVD risk, and cardio-respiratory fitness on dCA and cBRS. Linear models determined the relationship between dCA and cBRS.

RESULTS:

Age, sex, CVD risk, and cardio-respiratory fitness did not impact dCA normalised gain, phase, or coherence with minimal change in all models (P > 0.05). cBRS gain was attenuated with age when adjusted for sex and CVD risk (young-older; ß = - 2.86 P < 0.001) along with cBRS phase (young-older; ß = - 0.44, P < 0.001). There was no correlation between dCA normalised gain and phase with either parameter of cBRS.

CONCLUSION:

Ageing was associated with a decreased cBRS, but dCA appears to remain unchanged. Additionally, our data suggest that sex, CVD risk, and cardio-respiratory fitness have little effect.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Barorreflejo Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Barorreflejo Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article