The mitochondrial poison carbonyl cyanide 3-chlorophenyl hydrazone (CCCP) induces aneugenic effects in primary human fibroblasts: a possible link between mitochondrial dysfunction and chromosomal loss.

Marcon, Francesca; De Battistis, Francesca; Siniscalchi, Ester; Crebelli, Riccardo; Meschini, Roberta

Marcon, Francesca; De Battistis, Francesca; Siniscalchi, Ester; Crebelli, Riccardo; Meschini, Roberta.

Marcon F; Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Roma, Italy.
De Battistis F; Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Roma, Italy.
Siniscalchi E; Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Roma, Italy.
Crebelli R; Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Roma, Italy.
Meschini R; Department of Ecological and Biological Sciences, University Tuscia, Via San Camillo de Lellis, s.n.c. 01100, Viterbo, Italy.

Mutagenesis ; 37(2): 155-163, 2022 05 04.

Article en En | MEDLINE | ID: mdl-35443032

Asunto(s)

Hidrazonas; Venenos; Humanos; Carbonil Cianuro m-Clorofenil Hidrazona/metabolismo; Carbonil Cianuro m-Clorofenil Hidrazona/farmacología; Hidrazonas/metabolismo; Hidrazonas/farmacología; Aneugénicos/metabolismo; Venenos/metabolismo; Venenos/farmacología; Mitocondrias; Fibroblastos; ADN/metabolismo

Palabras clave

aneuploidy in somatic cells; mechanisms of genotoxicity; mitochondria

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Venenos / Hidrazonas Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Venenos / Hidrazonas Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article