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Inverse Relationship between Mean Corpuscular Volume and T-Score in Chronic Dialysis Patients.
Chiang, Ming-Hsiu; Yang, Chih-Yu; Kuo, Yi-Jie; Cheng, Chung-Yi; Huang, Shu-Wei; Chen, Yu-Pin.
  • Chiang MH; Department of General Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
  • Yang CY; Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan.
  • Kuo YJ; Institute of Clinical Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Cheng CY; Stem Cell Research Center, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Huang SW; Department of Orthopedics, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.
  • Chen YP; Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Medicina (Kaunas) ; 58(4)2022 Mar 30.
Article en En | MEDLINE | ID: mdl-35454336
ABSTRACT
Background and

Objectives:

Osteoporosis and anemia are prevalent among chronic kidney disease stage 5D (CKD stage 5D) patients. Osteoblasts are known as the niche cells of hematopoietic stem cells (HSCs) and stimulate HSCs to form blood-cell lineages within bone marrow microenvironments. We hypothesized that an inverse correlation may exist between mean corpuscular volume (MCV), a surrogate for ineffective hematopoiesis, and bone mineral density (BMD) in the CKD stage 5D population. Materials and

Methods:

This is a cross-sectional designed cohort study evaluating CKD stage 5D patients who have received dialysis therapy for over three months. Baseline clinical characteristics and laboratory data were prospectively collected. The dual-energy X-ray absorptiometry (DXA) method was used to measure BMD at five sites, which were bilateral femoral neck, total hip, and lumbar spine 1-4. The Pearson correlation test was initially adopted, and a multivariate linear regression model was further applied for potential confounder adjustments.

Results:

From September 2020 to January 2021, a total of 123 CKD stage 5D patients were enrolled. The Pearson correlation test revealed a significant inverse association between MCV and BMD at bilateral femoral neck and lumbar spine. The lowest T-score of the five body sites was determined as the recorded T-score. After adjustments for several potential confounding factors, the multivariate linear regression model found consistent negative associations between T-score and MCV.

Conclusions:

The present study found significant inverse correlations between MCV and BMD at specific body locations in patients on dialysis. A decreased T-score was also found to be associated with macrocytosis after adjustments for confounding variables. However, direct evidence for the causative etiology was lacking.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Fallo Renal Crónico Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Fallo Renal Crónico Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Año: 2022 Tipo del documento: Article