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High mortality from carbapenem-resistant Klebsiella pneumoniae bloodstream infection.
Soares de Moraes, Luana; Gomes Magalhaes, Gerusa Luciana; Material Soncini, João Gabriel; Pelisson, Marsileni; Eches Perugini, Marcia Regina; Vespero, Eliana Carolina.
  • Soares de Moraes L; Clinical and Laboratory Microbiology, Department of Pathology, Clinical and Toxicological Analysis, State University of Londrina, Paraná, Brazil.
  • Gomes Magalhaes GL; Clinical and Laboratory Microbiology, Department of Pathology, Clinical and Toxicological Analysis, State University of Londrina, Paraná, Brazil.
  • Material Soncini JG; Clinical and Laboratory Microbiology, Department of Pathology, Clinical and Toxicological Analysis, State University of Londrina, Paraná, Brazil.
  • Pelisson M; Clinical and Laboratory Microbiology, Department of Pathology, Clinical and Toxicological Analysis, State University of Londrina, Paraná, Brazil.
  • Eches Perugini MR; Clinical and Laboratory Microbiology, Department of Pathology, Clinical and Toxicological Analysis, State University of Londrina, Paraná, Brazil.
  • Vespero EC; Clinical and Laboratory Microbiology, Department of Pathology, Clinical and Toxicological Analysis, State University of Londrina, Paraná, Brazil. Electronic address: eliana.vespero@gmail.com.
Microb Pathog ; 167: 105519, 2022 Jun.
Article en En | MEDLINE | ID: mdl-35483557
ABSTRACT
In this study, it was evaluated clinical data of 107 patients with bloodstream infection (BSI) by Klebsiella pneumoniae and performed phenotypic and molecular analyzes in 50.5% (54/107) of the samples, those that showed a resistance profile to carbapenemics. The blaKPC gene was present in 90.4% (49/54) of the samples, blaNDM gene in one sample and, in 7.4% (4/54) of the samples, no carbapenemase gene was found. In the similarity analysis, it was found 4 main clones and 11 samples were not genetically related. The median age of the patients was 58 (40-70) years old and 60.7% (65/107) were male. When comparing two groups of patients with BSI due to K. pneumoniae with and without resistance to carbapenems, the variables ICU permanence, renal failure (IR), previous use of antimicrobials, Charlson's comorbidity index (ICCi), some invasive procedures and death showed a statistically significant difference (p < 0.05). And when relating death as a dependent variable, IR, liver failure and patients with BSI XDR or PDR, were predictors of increased mortality. Our study showed a higher mortality rate in patients with BSI due to carbapenem-resistant pneumonia with additional resistance or not to polymyxins.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones por Klebsiella / Bacteriemia / Sepsis / Enterobacteriaceae Resistentes a los Carbapenémicos Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones por Klebsiella / Bacteriemia / Sepsis / Enterobacteriaceae Resistentes a los Carbapenémicos Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2022 Tipo del documento: Article