Combining phenotypic profiling and targeted RNA-Seq reveals linkages between transcriptional perturbations and chemical effects on cell morphology: Retinoic acid as an example.

Nyffeler, Johanna; Willis, Clinton; Harris, Felix R; Taylor, Laura W; Judson, Richard; Everett, Logan J; Harrill, Joshua A

Nyffeler, Johanna; Willis, Clinton; Harris, Felix R; Taylor, Laura W; Judson, Richard; Everett, Logan J; Harrill, Joshua A.

Nyffeler J; Center for Computational Toxicology & Exposure, Office of Research and Development, US Environmental Protection Agency, Durham, NC 27711, United States of America; Oak Ridge Institute for Science and Education (ORISE) Postdoctoral Fellow, Oak Ridge, TN 37831, United States of America.
Willis C; Center for Computational Toxicology & Exposure, Office of Research and Development, US Environmental Protection Agency, Durham, NC 27711, United States of America.
Harris FR; Center for Computational Toxicology & Exposure, Office of Research and Development, US Environmental Protection Agency, Durham, NC 27711, United States of America; Oak Ridge Associated Universities (ORAU) National Student Services Contractor, Oak Ridge, TN 37831, United States of America.
Taylor LW; Center for Computational Toxicology & Exposure, Office of Research and Development, US Environmental Protection Agency, Durham, NC 27711, United States of America.
Judson R; Center for Computational Toxicology & Exposure, Office of Research and Development, US Environmental Protection Agency, Durham, NC 27711, United States of America.
Everett LJ; Center for Computational Toxicology & Exposure, Office of Research and Development, US Environmental Protection Agency, Durham, NC 27711, United States of America.
Harrill JA; Center for Computational Toxicology & Exposure, Office of Research and Development, US Environmental Protection Agency, Durham, NC 27711, United States of America. Electronic address: harrill.joshua@epa.gov.

Toxicol Appl Pharmacol ; 444: 116032, 2022 06 01.

Article en En | MEDLINE | ID: mdl-35483669

Asunto(s)

Neoplasias Óseas; Tretinoina; Humanos; Fenotipo; RNA-Seq; Receptores de Ácido Retinoico/genética; Tretinoina/farmacología; Estados Unidos

Palabras clave

Cell Painting; Computational Toxicology; Concentration-Response; High-Throughput Phenotypic Profiling

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tretinoina / Neoplasias Óseas Tipo de estudio: Prognostic_studies Límite: Humans País como asunto: America do norte Idioma: En Año: 2022 Tipo del documento: Article

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