Scalable synthesis of favipiravir via conventional and continuous flow chemistry.
RSC Adv
; 11(61): 38691-38693, 2021 Nov 29.
Article
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| MEDLINE
| ID: mdl-35493228
ABSTRACT
Decagram scale synthesis of favipiravir was performed in 9 steps using diethyl malonate as cheap starting material. Hydrogenation and bromination steps were achieved by employing a continuous flow reactor. The synthetic process provided a total of 16% yield and it is suitable for larger-scale synthesis and production.
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2021
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