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Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.
Zhang, Mian; Fisher, Ciarán; Gardner, Iain; Pan, Xian; Kilford, Peter; Bois, Frederic Y; Jamei, Masoud.
  • Zhang M; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Fisher C; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Gardner I; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Pan X; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Kilford P; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Bois FY; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom.
  • Jamei M; Certara UK Ltd, Simcyp Division, Level 2-Acero, Sheffield, United Kingdom masoud.jamei@certara.com.
Drug Metab Dispos ; 50(7): 957-967, 2022 07.
Article en En | MEDLINE | ID: mdl-35504655
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Citocromo P-450 CYP1A2 / Inhibidores del Citocromo P-450 CYP1A2 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Citocromo P-450 CYP1A2 / Inhibidores del Citocromo P-450 CYP1A2 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article