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Chukranoids A-I, isopimarane diterpenoids from Chukrasia velutina.
Nugroho, Alfarius Eko; Tange, Masaki; Kusakabe, Sumi; Hirasawa, Yusuke; Shirota, Osamu; Matsuno, Michiyo; Mizukami, Hajime; Tougan, Takahiro; Horii, Toshihiro; Morita, Hiroshi.
  • Nugroho AE; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Tange M; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Kusakabe S; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Hirasawa Y; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Shirota O; Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki City, Kagawa, 769-2193, Japan.
  • Matsuno M; The Kochi Prefectural Makino Botanical Garden, 4200-6 Godaisan, Kochi City, Kochi, 781-8125, Japan.
  • Mizukami H; The Kochi Prefectural Makino Botanical Garden, 4200-6 Godaisan, Kochi City, Kochi, 781-8125, Japan.
  • Tougan T; Research Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Horii T; Department of Malaria Vaccine Development, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Morita H; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo, 142-8501, Japan. moritah@hoshi.ac.jp.
J Nat Med ; 76(4): 756-764, 2022 Sep.
Article en En | MEDLINE | ID: mdl-35511335
ABSTRACT
Bioactivity guided separation of Chukrasia velutina root methanolic extract led to the isolation of nine new isopimarane diterpenoids, chukranoids A-I (1-9). The absolute configuration was then assigned by comparing the experimental CD spectra and the calculated CD spectra. Chukranoids A-I (1-9) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. It seems that conjugate system in the isopimarane skeleton may influence their antimalarial activity.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Meliaceae / Diterpenos / Antimaláricos Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Meliaceae / Diterpenos / Antimaláricos Idioma: En Año: 2022 Tipo del documento: Article