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N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction.
Gabe, Maria Buur Nordskov; Gasbjerg, Laerke Smidt; Gadgaard, Sarina; Lindquist, Peter; Holst, Jens Juul; Rosenkilde, Mette Marie.
  • Gabe MBN; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Gasbjerg LS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Gadgaard S; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Lindquist P; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Holst JJ; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Rosenkilde MM; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Br J Pharmacol ; 179(18): 4473-4485, 2022 09.
Article en En | MEDLINE | ID: mdl-35523760
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptido 1 Similar al Glucagón / Receptor del Péptido 1 Similar al Glucagón Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptido 1 Similar al Glucagón / Receptor del Péptido 1 Similar al Glucagón Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article