Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis <i>via</i> the LRP1-PI3K/AKT pathway.

He, Yingzi; Zheng, Zhiwei; Liu, Chang; Li, Wen; Zhao, Liping; Nie, Guohui; Li, Huawei

Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1-PI3K/AKT pathway.

He, Yingzi; Zheng, Zhiwei; Liu, Chang; Li, Wen; Zhao, Liping; Nie, Guohui; Li, Huawei.

He Y; ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Zheng Z; NHC Key Laboratory of Hearing Medicine (Fudan University), Shanghai 200031, China.
Liu C; ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Li W; NHC Key Laboratory of Hearing Medicine (Fudan University), Shanghai 200031, China.
Zhao L; ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Nie G; NHC Key Laboratory of Hearing Medicine (Fudan University), Shanghai 200031, China.
Li H; ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.

Acta Pharm Sin B ; 12(3): 1305-1321, 2022 Mar.

Article en En | MEDLINE | ID: mdl-35530135

Palabras clave

5-mC, 5-methylcytosine; ABR, auditory brainstem response; Apoptosis; Cisplatin; DNMT; DNMT, DNA methyltransferase; EdU, 5-ethynyl-2'-deoxyuridine; HCs, hair cells; Hair cell; IHCs, inner hair cells; LRP1, low-density lipoprotein receptor-related protein 1; MMP, mitochondrial membrane potential; Mitochondrial dysfunction; OCRs, oxygen consumption rates; OHCs, outer hair cells; PI, propidium iodide; RG108; ROS; ROS, reactive oxygen species; SGNs, spiral ganglion neurons; Spiral ganglion neurons; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling

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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2022 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2022 Tipo del documento: Article