A microfluidic thyroid-liver platform to assess chemical safety in humans.

Kühnlenz, Julia; Karwelat, Diana; Steger-Hartmann, Thomas; Raschke, Marian; Bauer, Sophie; Vural, Özlem; Marx, Uwe; Tinwell, Helen; Bars, Remi

Kühnlenz, Julia; Karwelat, Diana; Steger-Hartmann, Thomas; Raschke, Marian; Bauer, Sophie; Vural, Özlem; Marx, Uwe; Tinwell, Helen; Bars, Remi.

Kühnlenz J; CropScience Division, Toxicology, Bayer S.A.S., Lyon, France.
Karwelat D; TissUse GmbH, Berlin, Germany.
Steger-Hartmann T; Pharmaceuticals Division, Investigational Toxicology, Bayer AG, Berlin, Germany.
Raschke M; Pharmaceuticals Division, Investigational Toxicology, Bayer AG, Berlin, Germany.
Bauer S; Pharmaceuticals Division, Investigational Toxicology, Bayer AG, Berlin, Germany.
Vural Ö; TissUse GmbH, Berlin, Germany.
Marx U; Pharmaceuticals Division, Investigational Toxicology, Bayer AG, Berlin, Germany.
Tinwell H; Medical Biotechnology, Institute for Biotechnology, Technische Universität Berlin, Berlin, Germany.
Bars R; TissUse GmbH, Berlin, Germany.

ALTEX ; 40(1): 61-82, 2023.

Article en En | MEDLINE | ID: mdl-35536601

Asunto(s)

Seguridad Química; Glándula Tiroides; Animales; Humanos; Glándula Tiroides/metabolismo; Microfluídica; Hormonas Tiroideas/metabolismo; Hormonas Tiroideas/farmacología; Hígado; Receptores Citoplasmáticos y Nucleares/metabolismo; Receptores Citoplasmáticos y Nucleares/farmacología

Palabras clave

3D HepaRG spheroids; endocrine disruption; hepatic phase I and II enzymes; new approach methodologies (NAMs); organs-on-a-chip

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glándula Tiroides / Seguridad Química Límite: Animals / Humans Idioma: En Año: 2023 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google