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A nomogram as an indirect method to identify sarcopenia in patients with liver cirrhosis.
Hernández-Conde, Marta; Llop, Elba; Gómez-Pimpollo, Lucía; Blanco, Santiago; Rodríguez, Luis; Fernández Carrillo, Carlos; Perelló, Christie; López-Gómez, Marta; Martínez-Porras, José Luis; Fernández-Puga, Natalia; Van Den Brule, Enrique; Royuela, Ana; Calleja, José Luis.
  • Hernández-Conde M; Gastroenterology, Liver Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Llop E; Gastroenterology, Liver Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain; Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain
  • Gómez-Pimpollo L; Department of Radiology. IDIPHISA, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Blanco S; Gastroenterology, Liver Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Rodríguez L; Gastroenterology, Liver Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Fernández Carrillo C; Gastroenterology, Liver Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Perelló C; Gastroenterology, Liver Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • López-Gómez M; Gastroenterology, Liver Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Martínez-Porras JL; Gastroenterology, Liver Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Fernández-Puga N; Gastroenterology, Liver Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Van Den Brule E; Department of Radiology. IDIPHISA, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
  • Royuela A; Biostatistics Unit, IDIPHISA, CIBERESP, Madrid, Spain.
  • Calleja JL; Gastroenterology, Liver Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain; Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain
Ann Hepatol ; 27(5): 100723, 2022.
Article en En | MEDLINE | ID: mdl-35580823
ABSTRACT
INTRODUCTION AND

OBJECTIVES:

Sarcopenia is one of the most common complications of cirrhosis, associated with an increased risk of morbidity and mortality. It is therefore necessary to perform a proper nutritional evaluation in these patients. Although CT scans are the gold standard for diagnosing sarcopenia, they are not widely used in clinical practice. There is thus a need to find indirect methods for identifying sarcopenia in patients with cirrhosis. MATERIAL AND

METHODS:

This is a cross-sectional study consecutively including all cirrhotic outpatients who underwent CT scans.

RESULTS:

A total of 174 patients met all the inclusion criteria and none of exclusion criteria. Fifty-five patients (31.6%) showed sarcopenia on CT scans. Multivariate analysis revealed that the factors that were independently associated with the presence of sarcopenia on CT scans were male sex (OR 11.27, 95% CI 3.53-35.95; p<0.001), lower body mass index (BMI) (OR 1.22, 95% CI 1.11-1.34; p<0.001) and lower phase angle by bioelectrical impedance analysis (OR 2.83, 95% CI 1.74-4.6; p<0.001). With the variables identified from the multivariate study we developed a nomogram that allows ruling out the presence of sarcopenia. Our model rules out sarcopenia with an area under the receiver operating characteristic curve value of 0.8. The cutoff point of the probability to rule out sarcopenia was 0.6 (sensitivity 85%, specificity 73%, Youden index 0.58, PPV 82.5% and NPV 91.3%).

CONCLUSION:

Since CT scans involve exposure to radiation and their availability is limited, we propose using this nomogram as an indirect method to rule out sarcopenia in cirrhotic patients.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sarcopenia Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sarcopenia Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Año: 2022 Tipo del documento: Article