Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation.

Zhong, Weizhe; Rao, Zhuqing; Xu, Jian; Sun, Yu; Hu, Haoran; Wang, Ping; Xia, Yongxiang; Pan, Xiongxiong; Tang, Weiwei; Chen, Ziyi; Zhou, Haoming; Wang, Xuehao

Zhong, Weizhe; Rao, Zhuqing; Xu, Jian; Sun, Yu; Hu, Haoran; Wang, Ping; Xia, Yongxiang; Pan, Xiongxiong; Tang, Weiwei; Chen, Ziyi; Zhou, Haoming; Wang, Xuehao.

Zhong W; Hepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Rao Z; Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Nanjing, China.
Xu J; NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing, China.
Sun Y; Department of Anesthesiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Hu H; Hepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wang P; Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Nanjing, China.
Xia Y; NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing, China.
Pan X; Hepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Tang W; Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Nanjing, China.
Chen Z; NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing, China.
Zhou H; Hepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wang X; Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Nanjing, China.

Aging Cell ; 21(6): e13622, 2022 06.

Article en En | MEDLINE | ID: mdl-35599014

Asunto(s)

ADN Mitocondrial; Mitofagia; Animales; Citosol/metabolismo; ADN Mitocondrial/genética; ADN Mitocondrial/metabolismo; Humanos; Inflamación/metabolismo; Hígado/metabolismo; Macrófagos/metabolismo; Proteínas de la Membrana/metabolismo; Ratones; Mitocondrias/metabolismo; Mitofagia/genética; Nucleotidiltransferasas/metabolismo; Proteínas Quinasas/metabolismo; Transducción de Señal

Palabras clave

aging; macrophage; mitochondrial DNA; mitophagy; sterile inflammation; stimulator of interferon genes

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN Mitocondrial / Mitofagia Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN Mitocondrial / Mitofagia Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article