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Association of Dietary Fish and n-3 Unsaturated Fatty Acid Consumption with Diabetic Nephropathy from a District Hospital in Northern Taiwan.
Lin, Shih-Ping; Chen, Chiao-Ming; Wang, Kang-Ling; Wu, Kun-Lin; Li, Sing-Chung.
  • Lin SP; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei City 11031, Taiwan.
  • Chen CM; Department of Dietetics, Taoyuan Armed Forces General Hospital, Taoyuan, Taoyuan City 32551, Taiwan.
  • Wang KL; Department of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei City 10462, Taiwan.
  • Wu KL; General Clinical Research Center, Taipei Veterans General Hospital, Taipei City 11217, Taiwan.
  • Li SC; Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei City 11217, Taiwan.
Nutrients ; 14(10)2022 May 21.
Article en En | MEDLINE | ID: mdl-35631289
ABSTRACT
Nephropathy caused by diabetes mellitus (DM) is the main cause of end-stage renal disease (ESRD). To understand the association of dietary intake with renal function indicators among patients with diabetic nephropathy (DN), this cross-sectional study was conducted at the dietetic consultation clinic of the Taoyuan Armed Forces General Hospital in Taiwan. In total, 317 participants were recruited for this study. Patients with diabetes who had a urinary albumin-creatinine ratio (UACR) of ≥30 mg/g were defined as having DN. The anthropometric characteristics, blood biochemistry, and renal function of the participants were assessed. Furthermore, a semiquantitative food frequency questionnaire (SQFFQ) was administered to investigate the dietary intake of the participants in the DM and DN groups. The result showed that participants in the DN group were older, had longer diabetes duration and poorer glycemic control and renal function than those in the DM group. Logistic regression models revealed that intake of high-fat marine fishes had the lowest odds ratio (OR) for DN risk compared with other fishes (OR 0.868; 95% CI 0.781-0.965, p = 0.009). Shellfish, soybean products, and skim milk also provided better protective effects to decrease the risk of DN. A further analysis of polyunsaturated fatty acids revealed that Σn-3 PUFAs significantly reduced DN risk, while Σn-6 PUFAs did not, especially EPA (OR 0.821; 95% CI 0.688-0.979, p = 0.029) and DHA (OR 0.903; 95% CI 0.823-0.992, p = 0.033) regardless of whether the variables were adjusted, including diabetes duration, age, and HbA1c. Our findings suggest that a diet that incorporates high-fat fish, shellfish, soybean products, and a lower Σn-6/Σn-3 ratio can mitigate DN risk.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Diabetes Mellitus Tipo 2 / Nefropatías Diabéticas Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País como asunto: Asia Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Diabetes Mellitus Tipo 2 / Nefropatías Diabéticas Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País como asunto: Asia Idioma: En Año: 2022 Tipo del documento: Article