Bullous pemphigoid and milia: prevalence and clinical laboratory findings in a Brazilian sample.
An Bras Dermatol
; 97(4): 435-442, 2022.
Article
en En
| MEDLINE
| ID: mdl-35637051
ABSTRACT
BACKGROUND:
Bullous pemphigoid (BP) associated with milia lesions has been increasingly reported, but its prevalence has not been reported in a Brazilian BP population yet.OBJECTIVES:
To describe the occurrence and clinical-laboratorial findings of BP-milia association in a southeastern Brazilian sample.METHODS:
A descriptive study based on the medical charts of 102 BP patients was accomplished. Clinical and laboratory data of BP-milia patients were compiled. Total serum IgE measurements, immunoblot assays based on basement membrane zone antigens, and HLA-DQ alleles typing were performed.RESULTS:
Milia was evident in 8 (7.8%) BP patients, five males, aged between 46 and 88 years. Increased total IgE levels were determined in 7 (87.5%) of the eight patients. In five of eight patients, immunoblotting showed IgG reactivity against the BP180-NC16a domain but not against collagen VII or laminin-332; it also revealed reactivity against the BP180 C-terminal domain or LAD-1, or both in four of them. The HLA-DQB1*0301 and HLA-DQA1*0505 alleles were identified in three of five BP-milia patients. Moreover, three of five cases presented the HLA-DQB1*06 allelic group. STUDYLIMITATIONS:
HLA determination was performed in five patients.CONCLUSIONS:
Milia formation in BP patients seems to be less uncommon than previously admitted. Laboratory data revealed increased IgE; autoantibodies against the BP180 C-terminal domain or LAD-1, or both; and the HLA-DQB1*06 allelic group, described for the BP-milia association. Careful determination of antibodies against basement membrane zone molecules and HLA characterization in different populations may provide further insights into this association.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Penfigoide Ampolloso
/
Queratosis
Tipo de estudio:
Diagnostic_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
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Aged80
/
Humans
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Male
/
Middle aged
País como asunto:
America do sul
/
Brasil
Idioma:
En
Año:
2022
Tipo del documento:
Article